MEMORIA 2021 - Área 6. Inmunología, Microbiología y Enfermedades Infecciosas

Área 6. Inmunología, Microbiología y Enfermedades Infecciosas

OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO

Generar conocimiento científico de excelencia: el año 2021 muestra un crecimiento importante de la producción científica del área 6. Tanto en indicadores cuantitativos como cualitativos, convirtiéndose en el mejor de la serie histórica. Este aumento no ha tenido repercusión en el liderazgo científico que se mantiene claramente por encima del 50%.
Captación de talento científico: el año 2021 tuvo un gran impacto en el área 6 con la consesión de una nueva investigadora Miguel Servet. Además se ha duplicado el personal de apoyo a la investigación financiado con fondos propios de investigación (tanto públicos como privados) (pasando de 25 a 50 personas). El área ha crecido con la entrada de un nuevo grupo emergente liderado por una investigadora Ramón y Cajal.
Dinamizar la captación de recursos: la captación de recursos ha sido menor a 2020 pero de mayor cuantía, superando los 2.2 millones de euros. Destacamos la concesión como nodo coordinador de la Red Española de Terapias Avanzadas (RICORS). Los ingresos por investigación clínica también han aumentado notablemente siendo el mejor año de la serie histórica.

7 Grupos de Investigación

INMUNOLOGÍA E INMUNOTOLERANCIA EN TRASPLANTES Y ENFERMEDADES DE BASE INMUNOLÓGICA (CONSOLIDADO)
INMUNIDAD, INFLAMACIÓN Y CÁNCER (CONSOLIDADO)
TRASPLANTE HEMATOPOYÉTICO / TERAPIA CELULAR (CONSOLIDADO)
INMUNIDAD INNATA EN LA SALUD Y LA ENFERMEDAD (EMERGENTE)
PATOLOGÍA INFECCIOSA, MICROBIOLOGÍA CLÍNICA Y MEDICINA TROPICAL (EMERGENTE)
ONCOLOGÍA CLÍNICA Y TRASLACIONAL (CLÍNICO ASOCIADO)
AUTOFAGIA, RESPUESTA INMUNE Y TOLERANCIA EN PROCESOS PATOLÓGICOS (EMERGENTE)

INDICADORES GENERALES

Nº Publicaciones

720.65

Impacto Total

8.58

Impacto Medio

Tipo	Nº Pubs	FI total	FI Medio
Originales	69 (82.14%)	633.78	9.19
Revisiones	15 (17.86%)	86.87	5.79

72.62

Q1%

27.38

D1%

FI >= 15

Tipo	Nº Q1	Nº D1	Nº FI >= 15
Originales	47	18	7
Revisiones	14	5	0

INDICADORES DE LIDERAZGO

45 (54.0%)

Nº Publicaciones

242.99

Impacto Total

5.4

Impacto Medio

	Nº Pubs	FI total	FI Medio
Mujer	18 (40.0%)	103.0	5.72
Hombre	27 (60.0%)	139.99	5.18

62.22

Q1%

17.78

D1%

FI >= 15

	Nº Q1	Nº D1	Nº FI >= 15
Mujer	12	5	0
Hombre	16	3	0

OTROS INDICADORES

22.15

HCP10% (2017-2021)

44.29

HCP10 Liderado% (2017-2021)

11.43

HCP10 Lid. Mujeres% (2017-2021)

2.43

Crown (2017-2021)

69.05

Open Access%

33.33

Col. International%

* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.

INDICADORES EVOLUTIVOS

DESTACADAS

Lee L, Perez Oliva AB*, Martinez-Balsalobre E et al. UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Science Advances, 2021, 7, eabc7371, PMID: 34559557, FI: 14.957

Garcia de Guadiana-Romualdo L, Martinez Martinez M, Rodriguez Mulero MD, ..., Bernal-Morell E*. Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients. International Journal of Infectious Diseases, 2021, 111, 211-218, PMID: 34461254, FI: 12.074

Martinez-Morcillo FJ*, Canton-Sandoval J, Martinez-Navarro FJ, ..., Perez-Oliva AB*, ..., Mulero V*. NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. Plos Biology, 2021, 19, e3001455, PMID: 34748530, FI: 9.593

Alfaro R, Martinez-Banaclocha H, Llorente S, ..., Muro M. Computational Prediction of Biomarkers, Pathways, and New Target Drugs in the Pathogenesis of Immune-Based Diseases Regarding Kidney Transplantation Rejection. Frontiers in Immunology, 2021, 12, 800968, PMID: 34975915, FI: 8.786

Minguela A*, Salido EJ, Soto-Ramirez MF, ..., Campillo JA. Low-affinity immunoglobulin gamma Fc region receptor III-B (FcgammaRIIIB, CD16B) deficiency in patients with blood and immune system disorders. British Journal of Haematology, 2021, 195, 743-747, PMID: 34544201, FI: 8.615

LISTADO COMPLETO

Gutierrez-Gutierrez B, Del Toro MD, Borobia AM et al. COLABORADORES: Aznar Munoz E, Gil Divasson P, Gonzalez Muniz P, ..., Garcia Vazquez E et al. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study. Lancet Infectious Diseases, 2021, 21, 783-792, PMID: 33636145, FI: 71.421

Hodcroft EB, Zuber M, Nadeau S et al. COLABORADORES: Gonzalez-Candelas F, Goig GA, Chiner-Oms A, ..., Viedma E et al. Spread of a SARS-CoV-2 variant through Europe in the summer of 2020. Nature, 2021, 595, 707-712, PMID: 34098568, FI: 69.504

Lopez MG, Chiner-Oms A, Garcia de Viedma D, ..., Oliver A et al. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant. Nature Genetics, 2021, 53, 1405-1414, PMID: 34594042, FI: 41.307

Goicoechea I, Puig N, Cedena MT, ..., Moraleda JM et al. Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma. Blood, 2021, 137, 49-60, PMID: 32693406, FI: 25.476

Gonzalez-Cao M, Mayo de Las Casas C, Oramas J, ..., Cerezuela P et al. Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial. Nature Communications, 2021, 12, 7008, PMID: 34853302, FI: 17.694

Orkin C, Oka S, Philibert P, ..., Morell EB et al. Long-acting cabotegravir plus rilpivirine for treatment in adults with HIV-1 infection: 96-week results of the randomised, open-label, phase 3 FLAIR study. Lancet hiv, 2021, 8, e185-e196, PMID: 33794181, FI: 16.07

Orkin C, Bernal Morell E, Tan DHS et al. Initiation of long-acting cabotegravir plus rilpivirine as direct-to-injection or with an oral lead-in in adults with HIV-1 infection: week 124 results of the open-label phase 3 FLAIR study. Lancet hiv, 2021, 8, e668-e678, PMID: 34656207, FI: 16.07

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, ..., Cabas I et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy, 2021, 17, 1-382, PMID: 33634751, FI: 13.391

Rodriguez-Bano J, Pachon J, Carratala J et al. COLABORADORES: Aznar Munoz E, Gil Divasson P, Gonzalez Muniz P, ..., Garcia Vazquez E et al. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19). Clinical Microbiology and Infection, 2021, 27, 244-252, PMID: 32860964, FI: 13.31

Blanco JR, Cobos-Ceballos MJ, Navarro F, ..., Bernal E et al. Pulmonary long-term consequences of COVID-19 infections after hospital discharge. Clinical Microbiology and Infection, 2021, 27, 892-896, PMID: 33662544, FI: 13.31

Whitworth LJ, Troll R, Pagan AJ, Roca FJ et al. Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118, PMID: 33658385, FI: 12.779

Gonzalez-Cao M, Puertolas T, Riveiro M, ..., Cerezuela P et al. Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM). Journal for Immunotherapy of Cancer, 2021, 9, PMID: 33782108, FI: 12.469

Perez-Garcia JM, Llombart-Cussac A, G Cortes M, ..., Alonso JL et al. Pembrolizumab plus eribulin in hormone-receptor-positive, HER2-negative, locally recurrent or metastatic breast cancer (KELLY): An open-label, multicentre, single-arm, phase trial. European Journal of Cancer, 2021, 148, 382-394, PMID: 33794440, FI: 10.002

Koirala S, Borisov S, Danila E, ..., Bernal E et al. Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort. Pulmonology, 2021, 27, 403-412, PMID: 33753021, FI: 9.216

Guerreiro M, Planelles D, Aguilar-Gallardo C, ..., Blanquer M et al. Allogeneic hematopoietic stem cell transplant recipients in Spain: Human leukocyte antigen characteristics and diversity by high-resolution analysis. Hla, 2021, 97, 198-213, PMID: 33369244, FI: 8.762

Calabretta E, Moraleda JM, Iacobelli M et al. COVID-19-induced endotheliitis: emerging evidence and possible therapeutic strategies. British Journal of Haematology, 2021, 193, 43-51, PMID: 33538335, FI: 8.615

Guillamon CF, Gimeno L, Server G, ..., Minguela A*. Immunological Risk Stratification of Bladder Cancer Based on Peripheral Blood Natural Killer Cell Biomarkers. European Urology Oncology, 2021, 4, 246-255, PMID: 31411976, FI: 8.208

Ruiz-Rodriguez P, Frances-Gomez C, Chiner-Oms A, ..., Gonzalez-Candelas F et al. Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2. Mbio, 2021, 12, e0231521, PMID: 34781748, FI: 7.786

Bernal E, Gimeno L, Alcaraz MJ, ..., Minguela A*. Activating Killer-Cell Immunoglobulin-Like Receptors Are Associated With the Severity of Coronavirus Disease 2019. Journal of Infectious Diseases, 2021, 224, 229-240, PMID: 33928374, FI: 7.759

Baragano Raneros A, Rodriguez RM, Bernardo Florez A, ..., Minguela A et al. Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia. Oncoimmunology, 2021, 10, 1897294, PMID: 33796404, FI: 7.723

Gimeno L, Gonzalez-Lozano I, Soto-Ramirez MF, ..., Minguela A*. CD8+ T lymphocytes are sensitive to NKG2A/HLA-E licensing interaction: role in the survival of cancer patients. Oncoimmunology, 2021, 10, 1986943, PMID: 34676148, FI: 7.723

Munoz Resta I, Bedrina B, Martinez-Planes E et al. Detection of subcellular nitric oxide in mitochondria using a pyrylium probe: assays in cell cultures and peripheral blood. Journal of Materials Chemistry b, 2021, 9, 9885-9892, PMID: 34821904, FI: 7.571

Richardson E, Garcia-Bernal D, Calabretta E, ..., Moraleda JM. Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes. Expert Opinion on Therapeutic Targets, 2021, 25, 423-433, PMID: 34167431, FI: 6.797

Martinez-Sanz J, Blanco JR, Muriel A, ..., Bernal E et al. Weight changes after antiretroviral therapy initiation in CoRIS (Spain): a prospective multicentre cohort study. Journal of the International Aids Society, 2021, 24, e25732, PMID: 34036745, FI: 6.707

Martinez-Sanchez MV, Fuster JL, Campillo JA, ..., Minguela A*. Expression of NK Cell Receptor Ligands on Leukemic Cells Is Associated with the Outcome of Childhood Acute Leukemia. Cancers, 2021, 13, PMID: 34064810, FI: 6.575

de la Cruz-Merino L, Gion M, Cruz-Jurado J, ..., Alonso-Romero JL et al. Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study. Cancers, 2021, 13, PMID: 34771596, FI: 6.575

Vasco-Mogorron MA, Campillo JA, Periago A, ..., Minguela A. Proliferation to Apoptosis Tumor Cell Ratio as a Biomarker to Improve Clinical Management of Pre-Malignant and Symptomatic Plasma Cell Neoplasms. International Journal of Molecular Sciences, 2021, 22, PMID: 33918790, FI: 6.208

Luciano AM, Perez-Oliva AB*, Mulero V* et al. Bcl-xL: A Focus on Melanoma Pathobiology. International Journal of Molecular Sciences, 2021, 22, PMID: 33803452, FI: 6.208

Ramirez-Pavez TN, Martinez-Esparza M, Ruiz-Alcaraz AJ, ..., Garcia-Penarrubia P*. The Role of Peritoneal Macrophages in Endometriosis. International Journal of Molecular Sciences, 2021, 22, PMID: 34639133, FI: 6.208

Garcia-Bernal D, Garcia-Arranz M, Yanez RM et al. The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy. Frontiers in Cell and Developmental Biology, 2021, 9, 650664, PMID: 33796536, FI: 6.081

Gomez I, Thomas MC, Palacios G, ..., Carrilero B et al. Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease Patients Versus Healthy Subjects. Frontiers in Cellular and Infection Microbiology, 2021, 11, 722984, PMID: 34552885, FI: 6.073

Ruiz-Canada C, Bernabe-Garcia A, Liarte S, ..., Nicolas FJ*. Chronic Wound Healing by Amniotic Membrane: TGF-beta and EGF Signaling Modulation in Re-epithelialization. Frontiers in Bioengineering and Biotechnology, 2021, 9, 689328, PMID: 34295882, FI: 6.064

Odet S, Louvrier A, Meyer C, Nicolas FJ et al. Surgical Application of Human Amniotic Membrane and Amnion-Chorion Membrane in the Oral Cavity and Efficacy Evaluation: Corollary With Ophthalmological and Wound Healing Experiences. Frontiers in Bioengineering and Biotechnology, 2021, 9, 685128, PMID: 34178969, FI: 6.064

Alcaraz MJ*, Alcaraz A, Teruel-Montoya R, ..., Minguela A*, Bernal E*. Subclinical atherosclerosis and immune activation in young HIV-infected patients with telomere shortening. Aging-Us, 2021, 13, 18094-18105, PMID: 34310343, FI: 5.955

Vasco-Mogorron MA, Campillo JA, Periago A, ..., Minguela A*. Blood-based risk stratification for pre-malignant and symptomatic plasma cell neoplasms to improve patient management. American Journal of Cancer Research, 2021, 11, 2736-2753, PMID: 34249425, FI: 5.942

Minguela A*, Vasco-Mogorron MA, Campillo JA, ..., Periago A. Predictive value of 1q21 gain in multiple myeloma is strongly dependent on concurrent cytogenetic abnormalities and first-line treatment. American Journal of Cancer Research, 2021, 11, 4438-4454, PMID: 34659897, FI: 5.942

Blanco JR, Negredo E, Bernal E et al. Impact of HIV infection on aging and immune status. Expert Review of Anti-Infective Therapy, 2021, 19, 719-731, PMID: 33167724, FI: 5.854

Boix F, Legaz I, Minhas A, ..., Muro M. Identification of peripheral CD154(+) T cells and HLA-DRB1 as biomarkers of acute cellular rejection in adult liver transplant recipients. Clinical and Experimental Immunology, 2021, 203, 315-328, PMID: 33025622, FI: 5.732

Sanz JL, Rodriguez-Lozano FJ, Lopez-Gines C et al. Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro studies. Dental Materials, 2021, 37, e256-e268, PMID: 33573840, FI: 5.687

Arguelles A, Sanchez-Fresneda R, Martinez-Marmol E, ..., Arguelles JC*. A Specific Mixture of Propolis and Carnosic Acid Triggers a Strong Fungicidal Action against Cryptococcus neoformans. Antibiotics-Basel, 2021, 10, PMID: 34827333, FI: 5.222

Bueno C*, Martinez-Morga M, Garcia-Bernal D, ..., Martinez S. Differentiation of human adult-derived stem cells towards a neural lineage involves a dedifferentiation event prior to differentiation to neural phenotypes. Scientific Reports, 2021, 11, 12034, PMID: 34103613, FI: 4.996

Ferrer MD, Barrueco AS, Martinez-Beneyto Y, ..., Garcia-Vazquez E et al. Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2. Scientific Reports, 2021, 11, 24392, PMID: 34937855, FI: 4.996

Guerrero-Girones J, Ros-Valverde A, Pecci-Lloret MP, Rodriguez-Lozano FJ et al. Association between Pulpal-Periapical Pathology and Autoimmune Diseases: A Systematic Review. Journal of Clinical Medicine, 2021, 10, PMID: 34768405, FI: 4.964

Alfaro R, Legaz I, Jimenez-Coll V, ..., Muro M. MicroRNA Expression Changes in Kidney Transplant: Diagnostic Efficacy of miR-150-5p as Potential Rejection Biomarker, Pilot Study. Journal of Clinical Medicine, 2021, 10, PMID: 34206682, FI: 4.964

Pecci-Lloret MP, Guerrero-Girones J, Lopez-Gonzalez B, Rodriguez-Lozano FJ et al. Dental Treatments under General Anesthesia on Children with Special Health Care Needs Enrolled in the Spanish Dental Care Program. Journal of Clinical Medicine, 2021, 10, PMID: 33419107, FI: 4.964

Takaki KK, Roca FJ, Schramm G et al. Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response. Plos Neglected Tropical Diseases, 2021, 15, e0008814, PMID: 33465071, FI: 4.781

Perez-Anton E, Egui A, Thomas MC, Carrilero B et al. A proportion of CD4+ T cells from patients with chronic Chagas disease undergo a dysfunctional process, which is partially reversed by benznidazole treatment. Plos Neglected Tropical Diseases, 2021, 15, e0009059, PMID: 33539379, FI: 4.781

Galcera-Jornet E, Consuegra-Sanchez L, Galcera-Tomas J et al. Association between new-onset right bundle branch block and primary or secondary ventricular fibrillation in ST-segment elevation myocardial infarction. European Heart Journal-Acute Cardiovascular Care, 2021, 10, 918-925, PMID: 33993235, FI: 4.766

Sancho JM, Fernandez-Alvarez R, Gual-Capllonch F, ..., Moraleda JM et al. R-COMP versus R-CHOP as first-line therapy for diffuse large B-cell lymphoma in patients >/=60 years: Results of a randomized phase 2 study from the Spanish GELTAMO group. Cancer Medicine, 2021, 10, 1314-1326, PMID: 33492774, FI: 4.711

Di Chiacchio IM, Paiva IM, de Abreu DJM, ..., Mulero V* et al. Bee pollen as a dietary supplement for fish: Effect on the reproductive performance of zebrafish and the immunological response of their offspring. Fish & Shellfish Immunology, 2021, 119, 300-307, PMID: 34656757, FI: 4.622

Butt RT, Janjua OS, Qureshi SM, ..., Rodriguez-Lozano FJ et al. Dental Healthcare Amid the COVID-19 Pandemic. International Journal of Environmental Research and Public Health, 2021, 18, PMID: 34769526, FI: 4.614

Franco-Martinez L, Ceron JJ, Vicente-Romero MR, Bernal E et al. Salivary Ferritin Changes in Patients with COVID-19. International Journal of Environmental Research and Public Health, 2021, 19, PMID: 35010300, FI: 4.614

Jimeno-Almazan A, Pallares JG, Buendia-Romero A, ..., Bernal-Morel E et al. Post-COVID-19 Syndrome and the Potential Benefits of Exercise. International Journal of Environmental Research and Public Health, 2021, 18, PMID: 34067776, FI: 4.614

Garcia MD, Arguelles JC*. Trehalase inhibition by validamycin A may be a promising target to design new fungicides and insecticides. Pest Management Science, 2021, 77, 3832-3835, PMID: 33786994, FI: 4.462

Sanz JL, Soler-Doria A, Lopez-Garcia S, ..., Rodriguez-Lozano FJ* et al. Comparative Biological Properties and Mineralization Potential of 3 Endodontic Materials for Vital Pulp Therapy: Theracal PT, Theracal LC, and Biodentine on Human Dental Pulp Stem Cells. Journal of Endodontics, 2021, 47, 1896-1906, PMID: 34425148, FI: 4.422

Alfaro R, Legaz I, Gonzalez-Martinez G, ..., Muro M. Monitoring of B Cell in Kidney Transplantation: Development of a Novel Clusters Analysis and Role of Transitional B Cells in Transplant Outcome. Diagnostics, 2021, 11, PMID: 33916199, FI: 3.992

Bolarin JM, Perez-Carceles MD, Hernandez Del Rincon JP, ..., Legaz I*. Causes of Death and Survival in Alcoholic Cirrhosis Patients Undergoing Liver Transplantation: Influence of the Patient's Clinical Variables and Transplant Outcome Complications. Diagnostics, 2021, 11, PMID: 34072173, FI: 3.992

Alfaro R, Jaouad EKEB, Llorente S, ..., Muro M. Personalized Medicine for Kidney Transplantation: Association of Graft Survival and Acute Transplant Rejection with Genetic Variation in B Cell Activating Factor System Signaling. Omics-A Journal of Integrative Biology, 2021, 25, 725-737, PMID: 34714153, FI: 3.978

Capdevila-Gaudens P, Garcia-Abajo JM, Flores-Funes D, ..., Garcia-Estan J*. Depression, anxiety, burnout and empathy among Spanish medical students. Plos one, 2021, 16, e0260359, PMID: 34855803, FI: 3.752

Moreno-Rodriguez JA, Guerrero-Girones J, Rodriguez-Lozano FJ et al. Immediate Post-Extraction Short Implant Placement with Immediate Loading and without Extraction of an Impacted Maxillary Canine: Two Case Reports. Materials, 2021, 14, PMID: 34071018, FI: 3.748

Legaz I, Bolarin JM, Campillo JA, ..., Muro M*. Pretransplant ascites and encephalopathy and their influence on survival and liver graft rejection in alcoholic cirrhosis disease. Archives of Medical Science, 2021, 17, 682-693, PMID: 34025838, FI: 3.707

Legaz I*, Bolarin JM, Navarro E, ..., Alvarez Lopez R*. KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation. Archives of Medical Science, 2021, 17, 764-774, PMID: 34025847, FI: 3.707

Gil-Gallardo L*, Simon M, Iborra A, ..., Segovia M*. Chemiluminescent Microparticle Immunoassay for the Diagnosis of Congenital Chagas Disease: A Prospective Study in Spain. American Journal of Tropical Medicine and Hygiene, 2021, 105, 1701-1705, PMID: 34607304, FI: 3.707

Sanchez Martinez DA, Canadilla-Ferreira M, Henarejos PS, Alonso Romero JL. Analysis of adolescent oncology cases from 2008 through 2018 in a tertiary-level hospital: an opportunity for improvement. Future Oncology, 2021, 17, 1545-1551, PMID: 33626935, FI: 3.674

Rodriguez-Lozano FJ*, Lopez-Garcia S, Garcia-Bernal D et al. Cytocompatibility and bioactive properties of the new dual-curing resin-modified calcium silicate-based material for vital pulp therapy. Clinical Oral Investigations, 2021, 25, 5009-5024, PMID: 33638052, FI: 3.606

Martinez-Morcillo FJ, Canton-Sandoval J, Martinez-Menchon T, ..., Perez-Oliva AB*, ..., Mulero V*. Non-canonical roles of NAMPT and PARP in inflammation. Developmental and Comparative Immunology, 2021, 115, 103881, PMID: 33038343, FI: 3.605

Hermi F, Gomez-Abellan V, Perez-Oliva AB, ..., Sepulcre MP. The molecular, functional and phylogenetic characterization of PGE2 receptors reveals their different roles in the immune response of the teleost fish gilthead seabream (Sparus aurata L.). Developmental and Comparative Immunology, 2021, 114, 103803, PMID: 32738336, FI: 3.605

Tyrkalska SD, Candel S, Mulero V. The neutrophil inflammasome. Developmental and Comparative Immunology, 2021, 115, 103874, PMID: 32987011, FI: 3.605

Lopez-Garcia S, Pecci-Lloret MP, Garcia-Bernal D, ..., Rodriguez-Lozano FJ*. Are Denture Adhesives Safe for Oral Cells? Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry, 2021, 30, 65-70, PMID: 32656785, FI: 3.485

Lopez-Lopez V, Morales A, Garcia-Vazquez E et al. Humanitarian Surgical Missions in Times of COVID-19: Recommendations to Safely Return to a Sub-Saharan Africa Low-Resource Setting. World Journal of Surgery, 2021, 45, 1297-1305, PMID: 33611661, FI: 3.282

El Band JEK, Llorente S, Martinez-Garcia P, ..., Muro M. Evaluation of Antibodies Directed Against Two GPCRs, Anti-AT1R and Anti-ETAR, on Kidney Transplant Outcome. Current Protein & Peptide Science, 2021, 22, 745-757, PMID: 34967284, FI: 3.118

Lopez-Garcia S, Pecci-Lloret MP, Pecci-Lloret MR, ..., Garcia-Bernal D. Topical fluoride varnishes promote several biological responses on human gingival cells. Annals of Anatomy-Anatomischer Anzeiger, 2021, 237, 151723, PMID: 33857632, FI: 2.976

Lopez-Garcia S, Guerrero-Girones J, Pecci-Lloret MP, ..., Garcia-Bernal D. In Vitro Biocompatibility of CPP-ACP and Fluoride-containing Desensitizers on Human Gingival Cells. Operative Dentistry, 2021, 46, E264-E275, PMID: 34919730, FI: 2.937

Gomez Garcia LM, Escudero A, Mestre C, ..., Blanquer M et al. Phase 2 Clinical Trial of Infusing Haploidentical K562-mb15-41BBL-Activated and Expanded Natural Killer Cells as Consolidation Therapy for Pediatric Acute Myeloblastic Leukemia. Clinical Lymphoma Myeloma & Leukemia, 2021, 21, 328-337.e1, PMID: 33610500, FI: 2.822

Ruiz-Lafuente N, Minguela A, Muro M, Parrado A*. The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells. Molecular Biology Reports, 2021, 48, 4285-4294, PMID: 34110575, FI: 2.742

Soria-Juan B, Garcia-Arranz M, Llanos Jimenez L, ..., Castellanos G* et al. Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial). Trials, 2021, 22, 595, PMID: 34488845, FI: 2.728

Masia M, Padilla S, Estan G, ..., Bernal E et al. Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection. Trials, 2021, 22, 851, PMID: 34838115, FI: 2.728

Boix F, Alfaro R, Jimenez-Coll V, ..., Muro M. A high concentration of TGF-beta correlates with opportunistic infection in liver and kidney transplantation. Human Immunology, 2021, 82, 414-421, PMID: 33814194, FI: 2.211

Mutukula N, Man Z, Takahashi Y, Iniesta Martinez F et al. Generation of RRMS and PPMS specific iPSCs as a platform for modeling Multiple Sclerosis. Stem Cell Research, 2021, 53, 102319, PMID: 33894548, FI: 1.587

AYUDAS CONCEDIDAS EN 2021

TOTAL DE AYUDAS CONCEDIDAS

Nº Ayudas

2.2M €

Financiación

TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS

Nº Ayudas

0.39M €

Financiación

TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS

Nº Ayudas Europeas

0.16M €

Financiación Europea

Nº Ayudas Nacionales

0.93M €

Financiación Nacional

Nº Ayudas Regionales

0.0M €

Financiación Regional

TOTAL DE REDES CONCEDIDAS

Nº Ayudas

0.7M €

Financiación

OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)

Nº Ayudas

11.02K €

Financiación

PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2021

TOTAL AYUDAS

RECURSOS HUMANOS

REDES

PROYECTOS INTERNACIONALES

PROYECTOS NACIONALES

PROYECTOS REGIONALES

INICIADA EN 2021

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

ACTIVOS EN 2021

189

Nº Estudios

116

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

FACTURACIÓN EN 2021

0.77M €

Facturado

Nº Tesis (1 con mención internacional)