MEMORIA 2021 - Área 1. Hematología y Oncología Clínico

Área 1. Hematología y Oncología Clínico - Experimental. Genética Clínica

OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO

Generar conocimiento científico de excelencia: asistimos al mejor año en la serie histórica del Área 1 en cuanto a calidad científica de nuestras publicaciones, mejorando tanto indicadores cuantitativos (número de publicaciones o impacto medio) como cualitativos (HCP10% o índice CROWN).
Captación de talento científico: se han conseguido 4 ayudas de recursos humanos competitivas, destacando la concesión de una investigadora Miguel Servet. Además, gracias al aumento de la financiación se ha podido ampliar el personal de apoyo a la investigación que se tenía en 2020.
Dinamizar la captación de recursos: la captación de recursos ha aumentado notablemente con respecto a 2020. Principalmente gracias a la concesión del primer proyecto de Medicina de Precisión del IMIB. Este año se ha superado por primera vez la barrera de los 2M€ en ayudas competitivas. Se han conseguido mantener los ingresos por estudios de investigación clínica a pesar del impacto asistencial de la epidemia de COVID-19.

7 Grupos de Investigación

HEMATOLOGÍA Y ONCOLOGÍA MÉDICA CLÍNICO-EXPERIMENTAL (CONSOLIDADO)
CONTROL MOLECULAR DE LA PROLIFERACIÓN Y DIFERENCIACIÓN (CONSOLIDADO)
TERAPIAS MOLECULARES Y BIOMARCADORES DE TUMORES SÓLIDOS (CONSOLIDADO)
INTEGRACIÓN MORFOFUNCIONAL DE CÉLULAS Y TEJIDOS (CONSOLIDADO)
TROMBOEMBOLISMO VENOSO (CLÍNICO ASOCIADO)
METALOFÁRMACOS ANTITUMORALES NO CONVENCIONALES (CONSOLIDADO)
PATOLOGÍA MOLECULAR Y FARMACOGENÉTICA (CONSOLIDADO)

INDICADORES GENERALES

Nº Publicaciones

701.07

Impacto Total

7.15

Impacto Medio

Tipo	Nº Pubs	FI total	FI Medio
Originales	86 (87.76%)	613.1	7.13
Revisiones	12 (12.24%)	87.97	7.33

61.22

Q1%

19.39

D1%

FI >= 15

Tipo	Nº Q1	Nº D1	Nº FI >= 15
Originales	49	18	6
Revisiones	11	1	1

INDICADORES DE LIDERAZGO

53 (54.0%)

Nº Publicaciones

337.17

Impacto Total

6.36

Impacto Medio

	Nº Pubs	FI total	FI Medio
Mujer	32 (60.38%)	229.34	7.17
Hombre	21 (39.62%)	107.84	5.14

67.92

Q1%

15.09

D1%

FI >= 15

	Nº Q1	Nº D1	Nº FI >= 15
Mujer	26	6	1
Hombre	10	2	0

OTROS INDICADORES

23.09

HCP10% (2017-2021)

47.83

HCP10 Liderado% (2017-2021)

26.09

HCP10 Lid. Mujeres% (2017-2021)

1.55

Crown (2017-2021)

67.35

Open Access%

52.04

Col. International%

* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.

INDICADORES EVOLUTIVOS

DESTACADAS

Ortega Enrique*, Vigueras Gloria*, Jose Ballester Francisco, Ruiz Jose*. Targeting translation: a promising strategy for anticancer metallodrugs Coordination Chemistry Reviews, 2021, 446, PMID: null, FI: 24.833

de la Morena-Barrio ME*, Gindele R, Bravo-Perez C*, ..., Corral J* et al. High penetrance of inferior vena cava system atresia in severe thrombophilia caused by homozygous antithrombin Budapest 3 variant: Description of a new syndrome. American Journal of Hematology, 2021, 96, 1363-1373, PMID: 34324211, FI: 13.265

Sanchez-Del-Campo L, Marti-Diaz R, Montenegro MF, ..., Rodriguez-Lopez JN*. MITF induces escape from innate immunity in melanoma. Journal of Experimental & Clinical Cancer Research, 2021, 40, 117, PMID: 33789714, FI: 12.658

Arroyo AB*, Fernandez-Perez MP*, Del Monte A, ..., Gonzalez-Conejero R*, Martinez C*. miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis. Haematologica, 2021, 106, 1636-1646, PMID: 32586906, FI: 11.047

Lopez-Galvez R*, de la Morena-Barrio ME*, Minano A et al. Thrombin in the Activation of the Fluid Contact Phase in Patients with Hereditary Angioedema Carrying the F12 P.Thr309Lys Variant. Clinical Reviews in Allergy & Immunology, 2021, 60, 357-368, PMID: 33725261, FI: 10.817

LISTADO COMPLETO

Pleyer L, Leisch M, Kourakli A, ..., Jerez A et al. Outcomes of patients with chronic myelomonocytic leukaemia treated with non-curative therapies: a retrospective cohort study. Lancet Haematology, 2021, 8, e135-e148, PMID: 33513373, FI: 30.153

Alameda D, Goicoechea I, Vicari M, ..., de Arriba F et al. Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development. Blood, 2021, 138, 1583-1589, PMID: 34133718, FI: 25.476

Ribera JM, Morgades M, Ciudad J, ..., Amigo ML et al. Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome-negative adult lymphoblastic leukemia. Blood, 2021, 137, 1879-1894, PMID: 33150388, FI: 25.476

Fankhauser CD, Tran B, Pedregal M, ..., Gonzalez-Billalabeitia E et al. A Risk-benefit Analysis of Prophylactic Anticoagulation for Patients with Metastatic Germ Cell Tumours Undergoing First-line Chemotherapy. European Urology, 2021, 7, 1130-1136, PMID: 33032968, FI: 24.267

Frelinger AL 3rd, Rivera J, Connor DE et al. Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function: Communication from the ISTH SSC Subcommittee on Platelet Physiology. Journal of Thrombosis and Haemostasis, 2021, 19, 3193-3202, PMID: 34580997, FI: 16.036

Megy K, Downes K, Morel-Kopp MC, ..., Rivera J et al. GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis. Journal of Thrombosis and Haemostasis, 2021, 19, 2612-2617, PMID: 34355501, FI: 16.036

Paiva B, Vidriales MB, Sempere A, ..., Amigo ML et al. Impact of measurable residual disease by decentralized flow cytometry: a PETHEMA real-world study in 1076 patients with acute myeloid leukemia. Leukemia, 2021, 35, 2358-2370, PMID: 33526859, FI: 12.883

Martinez-Cuadron D, Serrano J, Gil C, ..., Amigo ML et al. Evolving treatment patterns and outcomes in older patients (>/=60 years) with AML: changing everything to change nothing? Leukemia, 2021, 35, 1571-1585, PMID: 33077867, FI: 12.883

Cuenca I, Alameda D, Sanchez-Vega B, ..., De Arriba F et al. Immunogenetic characterization of clonal plasma cells in systemic light-chain amyloidosis. Leukemia, 2021, 35, 245-249, PMID: 32203144, FI: 12.883

Sargas C, Ayala R, Chillon MC, ..., Amigo ML et al. Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project Haematologica, 2021, 106, 3079-3089, PMID: 33179471, FI: 11.047

Puig N, Hernandez MT, Rosinol L, ..., de Arriba F et al. Lenalidomide and dexamethasone with or without clarithromycin in patients with multiple myeloma ineligible for autologous transplant: a randomized trial. Blood Cancer Journal, 2021, 11, 101, PMID: 34021118, FI: 9.812

Solano C, Vazquez L, Gimenez E, ..., Heras I* et al. Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transplantation and Cell Therapy Group. American Journal of Transplantation, 2021, 21, 258-271, PMID: 32812351, FI: 9.369

Sires-Campos J*, Lambertos A, Delevoye C, ..., Garcia-Borron JC*. Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells. Cellular and Molecular Life Sciences, 2021, 79, 47, PMID: 34921635, FI: 9.207

Sanchez-Maldonado JM, Caliz R, Lopez-Nevot MA, ..., Conesa-Zamora P et al. Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts. Frontiers in Immunology, 2021, 12, 672255, PMID: 34777329, FI: 8.786

Martin I, Villamon E, Abellan R, ..., Jerez A et al. Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and genetic mutations. British Journal of Haematology, 2021, 194, 708-717, PMID: 34296432, FI: 8.615

Alvarez-Larran A, Angona A, Andrade-Campos M, ..., Ferrer-Marin F* et al. Cytoreductive treatment in patients with CALR-mutated essential thrombocythaemia: a study comparing indications and efficacy among genotypes from the Spanish Registry of Essential Thrombocythaemia. British Journal of Haematology, 2021, 192, 988-996, PMID: 32745264, FI: 8.615

Ortega-Forte E*, Rovira A, Gandioso A et al. COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents. Journal of Medicinal Chemistry, 2021, 64, 17209-17220, PMID: 34797672, FI: 8.039

Guirao-Abad JP*, Weichert M, Luengo-Gil G et al. Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus. Mbio, 2021, 12, e0273521, PMID: 34663092, FI: 7.786

Vigueras Gloria, Markova Lenka, Novohradsky Vojtech, ..., Cutillas Natalia* et al. A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death Inorganic Chemistry Frontiers, 2021, 8, PMID: null, FI: 7.779

Pinana JL, Xhaard A, Tridello G, ..., Heras I* et al. Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Infectious Diseases, 2021, 223, 1564-1575, PMID: 32860509, FI: 7.759

Jimenez-Fonseca P, Carmona-Bayonas A*, Martinez de Castro E et al. External validity of docetaxel triplet trials in advanced gastric cancer: are there patients who still benefit? Gastric Cancer, 2021, 24, 445-456, PMID: 32970266, FI: 7.701

Alvarez-Mancenido F, Jimenez-Fonseca P, Carmona-Bayonas A et al. Is advanced esophageal adenocarcinoma a distinct entity from intestinal subtype gastric cancer? Data from the AGAMENON-SEOM Registry. Gastric Cancer, 2021, 24, 926-936, PMID: 33651195, FI: 7.701

Bravo-Perez C, Serna MJ, Esteban J, ..., Corral J*, de la Morena-Barrio ME*. Anticoagulant therapy in patients with congenital FXI deficiency. Blood Advances, 2021, 5, 4083-4086, PMID: 34597376, FI: 7.637

Palma-Barqueros V, Bury L, Kunishima S, ..., Rivera J*. Expanding the genetic spectrum of TUBB1-related thrombocytopenia. Blood Advances, 2021, 5, 5453-5467, PMID: 34516618, FI: 7.637

Macauda A, Giaccherini M, Sainz J, ..., Jerez A et al. Do myeloproliferative neoplasms and multiple myeloma share the same genetic susceptibility loci? International Journal of Cancer, 2021, 148, 1616-1624, PMID: 33038278, FI: 7.316

Melaiu O, Macauda A, Sainz J, ..., Jerez A et al. Common gene variants within 3'-untranslated regions as modulators of multiple myeloma risk and survival. International Journal of Cancer, 2021, 148, 1887-1894, PMID: 33152124, FI: 7.316

Ortega E, Perez-Arnaiz C, Rodriguez V et al. A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapydagger. European Journal of Medicinal Chemistry, 2021, 222, 113600, PMID: 34144355, FI: 7.088

Marin-Quilez A, Garcia-Tunon I, Fernandez-Infante C, ..., Palma-Barqueros V et al. Characterization of the Platelet Phenotype Caused by a Germline RUNX1 Variant in a CRISPR/Cas9-Generated Murine Model. Thrombosis and Haemostasis, 2021, 121, 1193-1205, PMID: 33626581, FI: 6.681

Arroyo AB*, Aguila S*, Fernandez-Perez MP, ..., Martinez C*, Gonzalez-Conejero R*. miR-146a in Cardiovascular Diseases and Sepsis: An Additional Burden in the Inflammatory Balance? Thrombosis and Haemostasis, 2021, 121, 1138-1150, PMID: 33352593, FI: 6.681

Orlando C, de la Morena-Barrio B*, Pareyn I, ..., Vicente V*, ..., de la Morena-Barrio ME*. Antithrombin p.Thr147Ala: The First Founder Mutation in People of African Origin Responsible for Inherited Antithrombin Deficiency. Thrombosis and Haemostasis, 2021, 121, 182-191, PMID: 32920809, FI: 6.681

Bravo-Perez C*, Sola M, Teruel-Montoya R, ..., Jerez A*. Minimal Residual Disease in Multiple Myeloma: Something Old, Something New. Cancers, 2021, 13, PMID: 34503142, FI: 6.575

Bastos Oreiro M, Martin R, Gomez P, ..., Perez Ceballos E et al. SEGHI Study: Defining the Best Surveillance Strategy in Hodgkin Lymphoma after First-Line Treatment. Cancers, 2021, 13, PMID: 34067616, FI: 6.575

Turpin-Sevilla MDC, Perez-Sanz F, Garcia-Solano J, ..., Conesa-Zamora P*. Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features. Cancers, 2021, 13, PMID: 34680315, FI: 6.575

Alburquerque-Gonzalez B, Bernabe-Garcia A, Bernabe-Garcia M, ..., Conesa-Zamora P*. The FDA-Approved Antiviral Raltegravir Inhibits Fascin1-Dependent Invasion of Colorectal Tumor Cells In Vitro and In Vivo. Cancers, 2021, 13, PMID: 33670655, FI: 6.575

Garcia-Alfonso P, Munoz A, Jimenez-Castro J, ..., Carmona-Bayonas A et al. Early Clinical Experience with Trifluridine/Tipiracil for Refractory Metastatic Colorectal Cancer: The ROS Study. Cancers, 2021, 13, PMID: 34572740, FI: 6.575

Palma-Barqueros V, Revilla N, Sanchez A, ..., Rivera J*. Inherited Platelet Disorders: An Updated Overview. International Journal of Molecular Sciences, 2021, 22, PMID: 33926054, FI: 6.208

Bastida JM, Gonzalez-Porras JR, Rivera J, Lozano ML*. Role of Thrombopoietin Receptor Agonists in Inherited Thrombocytopenia. International Journal of Molecular Sciences, 2021, 22, PMID: 33919295, FI: 6.208

Barrachina MN, Izquierdo I, Hermida-Nogueira L, ..., Garcia-Barbera N et al. The PI3Kdelta Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential. International Journal of Molecular Sciences, 2021, 22, PMID: 33804911, FI: 6.208

Lozano ML*, Segu-Verges C, Coma M et al. Elucidating the Mechanism of Action of the Attributed Immunomodulatory Role of Eltrombopag in Primary Immune Thrombocytopenia: An In Silico Approach. International Journal of Molecular Sciences, 2021, 22, PMID: 34199099, FI: 6.208

Martinez-Menarguez JA, Martinez-Alonso E, Cara-Esteban M et al. Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson's Disease. International Journal of Molecular Sciences, 2021, 22, PMID: 34769517, FI: 6.208

Moros-Nicolas C, Chevret P, Jimenez-Movilla M, ..., Izquierdo-Rico MJ. New Insights into the Mammalian Egg Zona Pellucida. International Journal of Molecular Sciences, 2021, 22, PMID: 33806989, FI: 6.208

Aguila S*, Noto R, Luengo-Gil G, ..., Martinez-Martinez I*. N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function. International Journal of Molecular Sciences, 2021, 22, PMID: 33419227, FI: 6.208

Ferrer-Marin F, Cuenca-Zamora EJ, Guijarro-Carrillo PJ, Teruel-Montoya R*. Emerging Role of Neutrophils in the Thrombosis of Chronic Myeloproliferative Neoplasms. International Journal of Molecular Sciences, 2021, 22, PMID: 33498945, FI: 6.208

Aguila S*, de Los Reyes-Garcia AM*, Fernandez-Perez MP, ..., Gonzalez-Conejero R*, Martinez C*. MicroRNAs as New Regulators of Neutrophil Extracellular Trap Formation. International Journal of Molecular Sciences, 2021, 22, PMID: 33672737, FI: 6.208

Penas-Martinez J*, Barrachina MN, Cuenca-Zamora EJ, ..., Martinez-Martinez I*, Ferrer-Marin F*. Qualitative and Quantitative Comparison of Plasma Exosomes from Neonates and Adults. International Journal of Molecular Sciences, 2021, 22, PMID: 33672065, FI: 6.208

Jimenez-Movilla M, Hamze JG, Romar R. Oolemma Receptors in Mammalian Molecular Fertilization: Function and New Methods of Study. Frontiers in Cell and Developmental Biology, 2021, 9, 662032, PMID: 34095128, FI: 6.081

Fuentes-Albero MC, Gonzalez-Brusi L, Cots P et al. Protein Identification of Spermatozoa and Seminal Plasma in Bottlenose Dolphin (Tursiops truncatus). Frontiers in Cell and Developmental Biology, 2021, 9, 673961, PMID: 34336830, FI: 6.081

Gomez D, Jimenez-Fonseca P, Fernandez AM, ..., Carmona-Bayonas A et al. Impact of Obesity on Quality of Life, Psychological Distress, and Coping on Patients with Colon Cancer. Oncologist, 2021, 26, e874-e882, PMID: 33492756, FI: 5.837

de la Morena-Barrio ME*, Bravo-Perez C*, de la Morena-Barrio B, ..., Lozano ML*. A pilot study on the impact of congenital thrombophilia in COVID-19. European Journal of Clinical Investigation, 2021, 51, e13546, PMID: 33738814, FI: 5.722

Garcia de Guadiana-Romualdo L*, Calvo Nieves MD, Rodriguez Mulero MD et al. MR-proADM as marker of endotheliitis predicts COVID-19 severity. European Journal of Clinical Investigation, 2021, 51, e13511, PMID: 33569769, FI: 5.722

Jimenez-Fonseca P, Carmona-Bayonas A, Martinez-Torron A et al. External validity of clinical trials with diverse trastuzumab-based chemotherapy regimens in advanced gastroesophageal adenocarcinoma: data from the AGAMENON-SEOM registry. Therapeutic Advances in Medical Oncology, 2021, 13, 17588359211019672, PMID: 34211587, FI: 5.485

Zamora A*, Wachter E, Vera M, ..., Ruiz J*. Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences. Inorganic Chemistry, 2021, 60, 2178-2187, PMID: 33502194, FI: 5.436

Bravo-Perez C*, Fernandez-Caballero M, Soler-Espejo E, ..., de Arriba F*. Heparin versus aspirin thromboprophylaxis adds independent value to IMPEDE-VTE score for venous thrombosis prediction in multiple myeloma. Journal of Thrombosis and Thrombolysis, 2021, 52, 848-853, PMID: 33649980, FI: 5.221

Bento L, Gutierrez A, Novelli S, ..., Lopez-Godino O et al. Allogeneic stem cell transplantation as a curative option in relapse/refractory diffuse large B cell lymphoma: Spanish multicenter GETH/GELTAMO study. Bone Marrow Transplantation, 2021, 56, 1919-1928, PMID: 33767400, FI: 5.174

Solano C, Vazquez L, Gimenez E, ..., Heras I et al. Clinical outcomes of allogeneic hematopoietic stem cell transplant recipients developing Cytomegalovirus DNAemia prior to engraftment. Bone Marrow Transplantation, 2021, 56, 1281-1290, PMID: 33319853, FI: 5.174

Novohradsky V, Markova L, Kostrhunova H, ..., Ruiz J et al. A Cyclometalated Ir(III) Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells. Chemistry-A European Journal, 2021, 27, 8547-8556, PMID: 33835526, FI: 5.02

de la Morena-Barrio ME*, Bravo-Perez C*, Minano A, ..., Lozano ML*. Prognostic value of thrombin generation parameters in hospitalized COVID-19 patients. Scientific Reports, 2021, 11, 7792, PMID: 33833254, FI: 4.996

Garcia-Vazquez FA*, Moros-Nicolas C, Lopez-Ubeda R, ..., Izquierdo-Rico MJ. Evidence of haptoglobin in the porcine female genital tract during oestrous cycle and its effect on in vitro embryo production. Scientific Reports, 2021, 11, 12041, PMID: 34103548, FI: 4.996

Fernandez Montes A, Carmona-Bayonas A, Jimenez-Fonseca P et al. Prediction of survival in patients with advanced, refractory colorectal cancer in treatment with trifluridine/tipiracil: real-world vs clinical trial data. Scientific Reports, 2021, 11, 14321, PMID: 34253805, FI: 4.996

Ding WY, Rivera-Caravaca JM, Marin F, ..., Roldan V et al. Prediction of Residual Stroke Risk in Anticoagulated Patients with Atrial Fibrillation: mCARS. Journal of Clinical Medicine, 2021, 10, PMID: 34362143, FI: 4.964

Marce S, Xicoy B, Garcia O, ..., Teruel-Montoya R et al. Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib. Journal of Clinical Medicine, 2021, 10, PMID: 34300312, FI: 4.964

Ribera JM, Morgades M, Genesca E, ..., Amigo ML et al. Outcomes and prognostic factors of adults with refractory or relapsed T-cell acute lymphoblastic leukemia included in measurable residual disease-oriented trials. Hematological Oncology, 2021, 39, 529-538, PMID: 34405901, FI: 4.85

Penas-Martinez J, Luengo-Gil G, Espin S, ..., Martinez-Martinez I*. Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells. Biomedicines, 2021, 9, PMID: 34067120, FI: 4.757

Palma-Barqueros V, Bohdan N, Revilla N, ..., Rivera J*. PTGS1 gene variations associated with bleeding and platelet dysfunction. Platelets, 2021, 32, 710-716, PMID: 32584621, FI: 4.236

Bastida JM, Benito R, Gonzalez-Porras JR, Rivera J*. ABCG5 and ABCG8 gene variations associated with sitosterolemia and platelet dysfunction. Platelets, 2021, 32, 573-577, PMID: 32546081, FI: 4.236

Herraiz C, Martinez-Vicente I, Maresca V. The alpha-melanocyte-stimulating hormone/melanocortin-1 receptor interaction: A driver of pleiotropic effects beyond pigmentation. Pigment Cell & Melanoma Research, 2021, 34, 748-761, PMID: 33884776, FI: 4.159

Huerta-Retamal N, Saez-Espinosa P, Robles-Gomez L, Aviles M et al. Human sperm chaperone HSPA2 distribution during in vitro capacitation. Journal of Reproductive Immunology, 2021, 143, 103246, PMID: 33246276, FI: 3.993

Viudez A, Crespo G, Gomez Dorronsoro ML, ..., Carmona-Bayonas A et al. Usefulness of an immunohistochemical score in advanced pancreatic neuroendocrine tumors treated with CAPTEM or everolimus. Pancreatology, 2021, 21, 215-223, PMID: 33358592, FI: 3.977

Gonzalez-Rincon J, Garcia-Vela JA, Gomez S, ..., Garcia-Malo MD et al. Genomic mutation profile in progressive chronic lymphocytic leukemia patients prior to first-line chemoimmunotherapy with FCR and rituximab maintenance (REM). Plos one, 2021, 16, e0257353, PMID: 34506616, FI: 3.752

Genesca E, Morgades M, Gonzalez-Gil C, ..., Amigo ML et al. Adverse prognostic impact of complex karyotype (>/=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL). Leukemia Research, 2021, 109, 106612, PMID: 34139642, FI: 3.715

Perez Encinas MM, Sobas M, Gomez-Casares MT, ..., Ferrer-Marin F et al. The risk of thrombosis in essential thrombocythemia is associated with the type of CALR mutation: A multicentre collaborative study. European Journal of Haematology, 2021, 106, 371-379, PMID: 33275803, FI: 3.674

Parra Salinas I, Bermudez A, Lopez Corral L, Lopez Godino O et al. Treatment of steroid-refractory chronic graft-versus-host disease with imatinib: Real-life experience of the Spanish group of hematopoietic transplantation (GETH). Clinical Transplantation, 2021, 35, e14255, PMID: 33595866, FI: 3.456

Ayala de la Pena F*, Ortiz-Munoz B, Quintanar-Verduguez T et al. Consensus of the Spanish society of laboratory medicine and the Spanish society of medical oncology on the methodology and criteria for evaluation of circulating tumour markers in breast cancer. Clinical & Translational Oncology, 2021, 23, 1272-1280, PMID: 33550504, FI: 3.34

Munoz-Langa J, Jimenez-Fonseca P, Carmona-Bayonas A* et al. Rationale, design and methodology of TESEO study: a registry of thrombosis and neoplasia of SEOM (Spanish Society of Medical Oncology). Clinical & Translational Oncology, 2021, 23, 799-811, PMID: 32789772, FI: 3.34

Gomez D, Calderon C, Carmona-Bayonas A et al. Impact of adjuvant therapy toxicity on quality of life and emotional symptoms in patients with colon cancer: a latent class analysis. Clinical & Translational Oncology, 2021, 23, 657-662, PMID: 32676895, FI: 3.34

Calderon C, Gomez D, Carmona-Bayonas A et al. Social support, coping strategies and sociodemographic factors in women with breast cancer. Clinical & Translational Oncology, 2021, 23, 1955-1960, PMID: 33840046, FI: 3.34

Custodio A, Jimenez-Fonseca P, Carmona-Bayonas A et al. Use of healthcare REsources and associated COsts in controlled versus uncontrolled carcinoid SYndrome in patients with neuroendocrine tumours: the RECOSY study. Clinical & Translational Oncology, 2021, 23, 2046-2056, PMID: 34109562, FI: 3.34

Carmona-Bayonas A, Calderon C, Hernandez R et al. Prediction of quality of life in early breast cancer upon completion of adjuvant chemotherapy. Breast Cancer, 2021, 7, 92, PMID: 34257315, FI: 3.307

Munoz-Baquero M, Marco-Jimenez F, Garcia-Dominguez X, ..., Jimenez-Movilla M et al. Comparative Study of Semen Parameters and Hormone Profile in Small-Spotted Catshark (Scyliorhinus canicula): Aquarium-Housed vs. Wild-Captured. Animals, 2021, 11, PMID: 34679905, FI: 3.231

Lozano ML*, Sanz MA, Vicente V. Guidelines of the Spanish ITP Group for the diagnosis, treatment and follow-up of patients with immune thrombopenia. Medicina Clinica, 2021, 157, 191-198, PMID: 34088525, FI: 3.2

Boluda B, Martinez-Cuadron D, Algarra L, ..., Amigo ML et al. Evolving patterns of care and outcomes in relapsed/refractory FLT3 mutated acute myeloid leukemia adult patients. Leukemia & Lymphoma, 2021, 62, 2727-2736, PMID: 34121593, FI: 2.996

Pinero-Madrona A*, Nicolas-Ruiz F, Rull-Ortuno R et al. Correlation between ferromagnetic and isotopic tracers for sentinel lymph node detection in cutaneous melanoma: IMINEM study. Journal of Surgical Oncology, 2021, 123, 654-659, PMID: 33238054, FI: 2.885

Abrisqueta P, Loscertales J, Terol MJ, ..., Garcia Malo MD et al. Real-World Characteristics and Outcome of Patients Treated With Single-Agent Ibrutinib for Chronic Lymphocytic Leukemia in Spain (IBRORS-LLC Study). Clinical Lymphoma Myeloma & Leukemia, 2021, 21, e985-e999, PMID: 34511320, FI: 2.822

Amat P, Lopez-Corral L, Goterris R, ..., Lopez O et al. Biomarker profile predicts clinical efficacy of extracorporeal photopheresis in steroid-resistant acute and chronic graft-vs-host disease after allogenic hematopoietic stem cell transplant. Journal of Clinical Apheresis, 2021, 36, 697-710, PMID: 34185332, FI: 2.605

Lozano ML. Avatrombopag for the management of thrombocytopenia in patients with chronic liver disease. Revista Espanola de Enfermedades Digestivas, 2021, 113, 136-140, PMID: 33233913, FI: 2.389

Lozano ML, Mingot-Castellano ME, Perera MM, ..., Orna-Montero E*, Vicente V*. A decade of changes in management of immune thrombocytopenia, with special focus on elderly patients. Blood Cells Molecules and Diseases, 2021, 86, 102505, PMID: 32979651, FI: 2.372

Calderon C, Jimenez-Fonseca P, Hernandez R, ..., Carmona-Bayonas A. Prospective Study Comparing Clinicians' and Cancer Patients' Estimates of Risk of Relapse and Toxicity with Adjuvant Chemotherapy. Cancer Investigation, 2021, 39, 589-596, PMID: 34182858, FI: 2.368

Bueno F, Solano C, Vazquez L, ..., Heras I et al. Assessment of the association between cytomegalovirus DNAemia and subsequent acute graft-versus-host disease in allogeneic peripheral blood stem cell transplantation: A multicenter study from the Spanish hematopoietic transplantation and cell therapy group. , 2021, 23, e13627, PMID: 33908148, FI: 2.228

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Tomas M, Martinez-Alonso E, Martinez-Martinez N, ..., Martinez-Menarguez JA. Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: New cytopathological findings in Parkinson's disease. Histology and Histopathology, 2021, 36, 47-60, PMID: 33078843, FI: 2.13

Diaz-Flores L, Gutierrez R, Gonzalez-Gomez M, ..., Madrid JF. Myriad pillars formed by intussusceptive angiogenesis as the basis of intravascular papillary endothelial hyperplasia (IPEH). IPEH is intussusceptive angiogenesis made a lesion. Histology and Histopathology, 2021, 36, 217-228, PMID: 33336356, FI: 2.13

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AYUDAS CONCEDIDAS EN 2021

TOTAL DE AYUDAS CONCEDIDAS

Nº Ayudas

2.2M €

Financiación

TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS

Nº Ayudas

0.55M €

Financiación

TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS

Nº Ayudas Europeas

0.0M €

Financiación Europea

Nº Ayudas Nacionales

1.62M €

Financiación Nacional

Nº Ayudas Regionales

0.03M €

Financiación Regional

TOTAL DE REDES CONCEDIDAS

Nº Ayudas

0.0M €

Financiación

OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)

Nº Ayudas

0.0K €

Financiación

PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2021

TOTAL AYUDAS

RECURSOS HUMANOS

REDES

PROYECTOS INTERNACIONALES

PROYECTOS NACIONALES

PROYECTOS REGIONALES

INICIADA EN 2021

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

ACTIVOS EN 2021

119

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

FACTURACIÓN EN 2021

0.4M €

Facturado

Nº Tesis (1 con mención internacional)