Área 4. Neurociencias y Órganos de los Sentidos
OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO
- Generar conocimiento científico de excelencia: el Área 4 ha mejorado notablemente su producción científica, consiguiendo los mejores números en la serie histórica, tanto en los indicadores cuantitativos como los cualitativos. Además ha aumentado hasta el 72% el liderazgo de sus publicaciones, aunque debe mejorar en los indicadores de colaboración internacional.
- Captación de talento científico: la captación de recursos humanos competitivos ha sido la asignatura pendiente de 2021, ya que no hemos sido capaces de encontrar candidatos para presentar a convocatorias competitivas. Aún así, gracias a la financiación propia de los grupos del área, el número de personas de apoyo a la investigación ha aumentado de 11 a 22 personas. El área ha aumentado con un nuevo grupo de investigación clínico asociado.
- Dinamizar la captación de recursos: la captación de recursos competitiva ha sido menor que en años anteriores, pero se mantiene el liderazgo femenino en la concesión de ayudas. Destacamos la participación en la red Española de Enfermedades Inflamatorias (RICORS). La facturación por investigación clínica también se ha resentido debido probablemente a los efectos del segundo año de pandemia.
- Personal
- Publicaciones
- Listado Publicaciones
- Ayudas de Investigación
- Investigación Clínica
- Tesis Doctorales
8
Grupos de Investigación
- OFTALMOLOGÍA EXPERIMENTAL (CONSOLIDADO)
- FARMACOLOGÍA CELULAR Y MOLECULAR (CONSOLIDADO)
- REGIONALIZACION CEREBRAL Y GENES DEL DESARROLLO (CONSOLIDADO)
- NEUROCIENCIA CLÍNICA Y EXPERIMENTAL (CONSOLIDADO)
- PSICOBIOLOGÍA Y NEUROBIOLOGÍA DEL COMPORTAMIENTO (CONSOLIDADO)
- ENVEJECIMIENTO CEREBRAL Y DEMENCIAS (EMERGENTE)
- NEUROINTERVENCIONISMO (EMERGENTE)
- OFTALMOLOGÍA CLÍNICA (CLÍNICO ASOCIADO)
INDICADORES GENERALES
53
Nº Publicaciones
389.63
Impacto Total
7.35
Impacto Medio
| Tipo | Nº Pubs | FI total | FI Medio |
| Originales | 47 (88.68%) | 356.21 | 7.58 |
| Revisiones | 6 (11.32%) | 33.41 | 5.57 |
67.92
Q1%
28.3
D1%
2
FI >= 15
| Tipo | Nº Q1 | Nº D1 | Nº FI >= 15 |
| Originales | 31 | 13 | 2 |
| Revisiones | 5 | 2 | 0 |
INDICADORES DE LIDERAZGO
38
(72.0%)
Nº Publicaciones
191.75
Impacto Total
5.05
Impacto Medio
| Nº Pubs | FI total | FI Medio | |
| Mujer | 12 (31.58%) | 65.0 | 5.42 |
| Hombre | 26 (68.42%) | 126.75 | 4.88 |
68.42
Q1%
28.95
D1%
0
FI >= 15
| Nº Q1 | Nº D1 | Nº FI >= 15 | |
| Mujer | 11 | 3 | 0 |
| Hombre | 15 | 8 | 0 |
OTROS INDICADORES
26.03
HCP10% (2017-2021)
65.08
HCP10 Liderado% (2017-2021)
30.16
HCP10 Lid. Mujeres% (2017-2021)
1.8
Crown (2017-2021)
77.36
Open Access%
35.85
Col. International%
* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.
INDICADORES EVOLUTIVOS
DESTACADAS
Madrid-Valero JJ*, Rubio-Aparicio M, Gregory AM, ..., Ordonana JR*.
The heritability of insomnia: Systematic review and meta-analysis of twin studies.
Sleep Medicine Reviews, 2021, 58, 101437, PMID: 33556853, FI: 11.401
Arrambide G, Llaneza-Gonzalez MA, Costa-Frossard Franca L, ..., Meca-Lallana JE.
SARS-CoV-2 Infection in Multiple Sclerosis: Results of the Spanish Neurology Society Registry.
Neurology-Neuroimmunology & Neuroinflammation, 2021, 8, PMID: 34168057, FI: 11.36
Madrid-Valero JJ, Barclay NL, Rowe R et al.
Association between symptoms of sleep apnea and problem behaviors in young adult twins and siblings.
Psychological Medicine, 2021, 51, 1175-1182, PMID: 32026794, FI: 10.592
Costa T, Fernandez-Villalba E, Izura V, ..., Herrero MT.
Combined 1-Deoxynojirimycin and Ibuprofen Treatment Decreases Microglial Activation, Phagocytosis and Dopaminergic Degeneration in MPTP-Treated Mice.
Journal of Neuroimmune Pharmacology, 2021, 16, 390-402, PMID: 32564332, FI: 7.285
Miralles de Imperial-Ollero JA, Gallego-Ortega A, Norte-Munoz M, ..., Vidal-Sanz M*.
Short- and Long-Term Study of the Impact of Focal Blue Light-Emitting Diode-Induced Phototoxicity in Adult Albino Rats.
International Journal of Molecular Sciences, 2021, 22, PMID: 34575905, FI: 6.208
LISTADO COMPLETO
Chitnis T, Banwell B, Kappos L et al. COLABORADORES: Dubois B, Verhelst H, Bojinova-Tchamova V, ..., Meca-Lallana J et al.
Safety and efficacy of teriflunomide in paediatric multiple sclerosis (TERIKIDS): a multicentre, double-blind, phase 3, randomised, placebo-controlled trial.
Lancet Neurology, 2021, 20, 1001-1011, PMID: 34800398, FI: 59.935
Reich DS, Arnold DL, Vermersch P et al. COLABORADORES: Grand'Maison F, Jacques F, Traboulsee A, ..., Meca-Lallana J et al.
Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial.
Lancet Neurology, 2021, 20, 729-738, PMID: 34418400, FI: 59.935
Fernandez-Velasco JI, Kuhle J, Monreal E, ..., Meca-Lallana J et al.
Effect of Ocrelizumab in Blood Leukocytes of Patients With Primary Progressive MS.
Neurology-Neuroimmunology & Neuroinflammation, 2021, 8, PMID: 33408167, FI: 11.36
Brigas HC, Ribeiro M, Coelho JE, ..., Gomez-Murcia V et al.
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease.
Cell Reports, 2021, 36, 109574, PMID: 34469732, FI: 9.995
Wang Y, Chen S, Wang J, ..., Vidal-Sanz M et al.
MicroRNA-93/STAT3 signalling pathway mediates retinal microglial activation and protects retinal ganglion cells in an acute ocular hypertension model.
Cell Death & Disease, 2021, 12, 41, PMID: 33414426, FI: 9.685
Walo-Delgado PE, Monreal E, Medina S, ..., Meca-Lallana J et al.
Role of B Cell Profile for Predicting Secondary Autoimmunity in Patients Treated With Alemtuzumab.
Frontiers in Immunology, 2021, 12, 760546, PMID: 34691084, FI: 8.786
Perez-Sanchez J, Carrillo de Gea JM, Rodriguez Barcelo S, Toval A et al.
Intracranial pressure analysis software: A mapping study and proposal.
Computer Methods and Programs in Biomedicine, 2021, 209, 106334, PMID: 34450483, FI: 7.027
Guerrero-Bautista R, Franco-Garcia A, Hidalgo JM, ..., Milanes MV*, Nunez C*.
Distinct Regulation of Dopamine D3 Receptor in the Basolateral Amygdala and Dentate Gyrus during the Reinstatement of Cocaine CPP Induced by Drug Priming and Social Stress.
International Journal of Molecular Sciences, 2021, 22, PMID: 33803578, FI: 6.208
Martinez-Vacas A, Di Pierdomenico J, Valiente-Soriano FJ, ..., Villegas-Perez MP*, Garcia-Ayuso D*.
Glial Cell Activation and Oxidative Stress in Retinal Degeneration Induced by beta-Alanine Caused Taurine Depletion and Light Exposure.
International Journal of Molecular Sciences, 2021, 23, PMID: 35008772, FI: 6.208
Martinez-Carmona M*, Lucas-Ruiz F, Gallego-Ortega A, ..., Agudo-Barriuso M*.
Ly6c as a New Marker of Mouse Blood Vessels: Qualitative and Quantitative Analyses on Intact and Ischemic Retinas.
International Journal of Molecular Sciences, 2021, 23, PMID: 35008441, FI: 6.208
Gallego-Ortega A, Vidal-Villegas B, Norte-Munoz M, ..., Vidal-Sanz M*.
7,8-Dihydroxiflavone Maintains Retinal Functionality and Protects Various Types of RGCs in Adult Rats with Optic Nerve Transection.
International Journal of Molecular Sciences, 2021, 22, PMID: 34769247, FI: 6.208
Galindo-Romero C*, Vidal-Villegas B, Asis-Martinez J, ..., Vidal-Sanz M.
7,8-Dihydroxiflavone Protects Adult Rat Axotomized Retinal Ganglion Cells through MAPK/ERK and PI3K/AKT Activation.
International Journal of Molecular Sciences, 2021, 22, PMID: 34639236, FI: 6.208
Gonzalez-Riquelme MJ*, Galindo-Romero C, Lucas-Ruiz F, ..., Agudo-Barriuso M*.
Axonal Injuries Cast Long Shadows: Long Term Glial Activation in Injured and Contralateral Retinas after Unilateral Axotomy.
International Journal of Molecular Sciences, 2021, 22, PMID: 34445225, FI: 6.208
Fernandez-Albarral JA, Salazar JJ, de Hoz R, ..., Aviles-Trigueros M et al.
Retinal Molecular Changes Are Associated with Neuroinflammation and Loss of RGCs in an Experimental Model of Glaucoma.
International Journal of Molecular Sciences, 2021, 22, PMID: 33669765, FI: 6.208
Lopez-Gonzalez L, Alonso A, Garcia-Calero E, ..., Puelles L*.
Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling.
Frontiers in Cell and Developmental Biology, 2021, 9, 676121, PMID: 34095148, FI: 6.081
Norte-Munoz M, Lucas-Ruiz F, Gallego-Ortega A, ..., Agudo-Barriuso M*.
Neuroprotection and Axonal Regeneration Induced by Bone Marrow Mesenchymal Stromal Cells Depend on the Type of Transplant.
Frontiers in Cell and Developmental Biology, 2021, 9, 772223, PMID: 34805178, FI: 6.081
Lucas-Ruiz F*, Galindo-Romero C, Albaladejo-Garcia V, ..., Agudo-Barriuso M*.
Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system.
Neural Regeneration Research, 2021, 16, 2125-2131, PMID: 33818483, FI: 6.058
Garrigos D, Martinez-Morga M, Toval A, ..., Ferran JL*.
A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review.
Frontiers in Endocrinology, 2021, 12, 638261, PMID: 34040580, FI: 6.055
Ausili A, Gomez-Murcia V, Candel AM, ..., Gomez-Fernandez JC.
A comparison of the location in membranes of curcumin and curcumin-derived bivalent compounds with potential neuroprotective capacity for Alzheimer's disease.
Colloids and Surfaces B-Biointerfaces, 2021, 199, 111525, PMID: 33373844, FI: 5.999
Toval A*, Garrigos D, Kutsenko Y, ..., Ferran JL*.
Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors.
Molecular Neurobiology, 2021, 58, 1782-1791, PMID: 33394335, FI: 5.682
Fernandez-Diaz E, Perez-Vicente JA, Villaverde-Gonzalez R et al.
Real-world experience of ocrelizumab in multiple sclerosis in a Spanish population.
Annals of Clinical and Translational Neurology, 2021, 8, 385-394, PMID: 33369288, FI: 5.43
Montagud-Romero S, Cantacorps L, Fernandez-Gomez FJ et al.
Unraveling the molecular mechanisms involved in alcohol intake and withdrawal in adolescent mice exposed to alcohol during early life stages.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2021, 104, 110025, PMID: 32599136, FI: 5.201
Kutsenko Y, Barreda A, Toval A, ..., Ferran JL*.
Sex-dependent effects of forced exercise in the body composition of adolescent rats.
Scientific Reports, 2021, 11, 10154, PMID: 33980961, FI: 4.996
Pusti D, Benito A, Madrid-Valero JJ et al.
Disparity between central and peripheral refraction inheritance in twins.
Scientific Reports, 2021, 11, 12196, PMID: 34108506, FI: 4.996
Miralles de Imperial-Ollero JA, Gallego-Ortega A, Norte-Munoz M, ..., Vidal-Sanz M*.
An in vivo model of focal light emitting diode-induced cone photoreceptor phototoxicity in adult pigmented mice: Protection with bFGF.
Experimental eye Research, 2021, 211, 108746, PMID: 34450185, FI: 3.77
Vidal-Villegas B, Di Pierdomenico J, Gallego-Ortega A, ..., Vidal-Sanz M.
Systemic treatment with 7,8-Dihydroxiflavone activates TtkB and affords protection of two different retinal ganglion cell populations against axotomy in adult rats.
Experimental eye Research, 2021, 210, 108694, PMID: 34245756, FI: 3.77
Meca-Lallana JE*, Oreja-Guevara C, Munoz D et al.
Four-year safety and effectiveness data from patients with multiple sclerosis treated with fingolimod: The Spanish GILENYA registry.
Plos one, 2021, 16, e0258437, PMID: 34644366, FI: 3.752
Meca-Lallana JE*, Maurino J, Perez-Miralles F et al.
Quantifying the patient s perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire.
Plos one, 2021, 16, e0255317, PMID: 34324586, FI: 3.752
Alonso A, Trujillo CM, Puelles L.
Quail-chick grafting experiments corroborate that Tbr1-positive eminential prethalamic neurons migrate along three streams into hypothalamus, subpallium and septocommissural areas.
Brain Structure & Function, 2021, 226, 759-785, PMID: 33544184, FI: 3.748
Garcia-Calero E, Puelles L.
Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression.
Brain Structure & Function, 2021, 226, 575-600, PMID: 33515280, FI: 3.748
Garcia-Calero E, Lopez-Gonzalez L, Martinez-de-la-Torre M, ..., Puelles L.
Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.
Brain Structure & Function, 2021, 226, 519-562, PMID: 33492553, FI: 3.748
Ortega F, Gomez-Villafuertes R, Benito-Leon M, Martinez de la Torre M et al.
Salient brain entities labelled in P2rx7-EGFP reporter mouse embryos include the septum, roof plate glial specializations and circumventricular ependymal organs.
Brain Structure & Function, 2021, 226, 715-741, PMID: 33427974, FI: 3.748
Navarro-Zaragoza J*, Martinez-Laorden E, Teruel-Fernandez FJ, ..., Almela P.
Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis.
Pharmacology Biochemistry and Behavior, 2021, 201, 173106, PMID: 33444599, FI: 3.697
Ho EK, Ferreira M, Pinheiro M, ..., Ordonana J* et al.
Factors associated with seeking medical care for low back pain in a twin adult sample.
European Journal of Pain, 2021, 25, 1091-1106, PMID: 33469982, FI: 3.651
Puelles L*.
Recollections on the Origins and Development of the Prosomeric Model.
Frontiers in Neuroanatomy, 2021, 15, 787913, PMID: 35002639, FI: 3.543
Garcia-Guillen IM, Martinez-de-la-Torre M, Puelles L, ..., Marin F*.
Molecular Segmentation of the Spinal Trigeminal Nucleus in the Adult Mouse Brain.
Frontiers in Neuroanatomy, 2021, 15, 785840, PMID: 34955765, FI: 3.543
van Groen T, Kadish I, Popovic N, ..., Popovic M*.
Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus.
Frontiers in Neuroanatomy, 2021, 15, 656882, PMID: 33994960, FI: 3.543
Garcia-Guillen IM, Alonso A, Puelles L, ..., Aroca P*.
Multiple Regionalized Genes and Their Putative Networks in the Interpeduncular Nucleus Suggest Complex Mechanisms of Neuron Development and Axon Guidance.
Frontiers in Neuroanatomy, 2021, 15, 643320, PMID: 33664652, FI: 3.543
Miralles de Imperial-Ollero JA, Gallego-Ortega A, Ortin-Martinez A, ..., Vidal-Sanz M*.
Animal Models of LED-Induced Phototoxicity. Short- and Long-Term In Vivo and Ex Vivo Retinal Alterations.
Life-Basel, 2021, 11, PMID: 34833013, FI: 3.251
Venketasubramanian N, Anderson C, Ay H, ..., Parrilla G et al.
Stroke Care during the COVID-19 Pandemic: International Expert Panel Review.
Cerebrovascular Diseases, 2021, 50, 245-261, PMID: 33756459, FI: 3.104
Cabrera-Maqueda JM, Alba-Isasi MT, Diaz-Perez J*, ..., Parrilla G*.
Bridging Therapy and Occlusion Site Influence Symptomatic Hemorrhage Rate after Thrombectomy: A Daily Practice Study in 623 Stroke Patients.
Cerebrovascular Diseases, 2021, 50, 279-287, PMID: 33706319, FI: 3.104
Puelles L, Diaz C, Stuhmer T et al.
LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus.
Journal of Comparative Neurology, 2021, 529, 367-420, PMID: 32420617, FI: 3.028
Paez-Granda D, Parrilla G, Diaz-Perez J, ..., Zamarro J.
Are modified Fisher Scale and bleeding pattern helpful predictors of neurological complications in non-aneurysmal subarachnoid hemorrhage?
Neuroradiology, 2021, 63, 253-257, PMID: 32812071, FI: 2.995
Madrid-Valero JJ*, Chapman R, Bailo E et al.
What Do People Know About the Heritability of Sleep?
Behavior Genetics, 2021, 51, 144-153, PMID: 33486622, FI: 2.965
Meca-Lallana JE*, Prefasi D, Perez-Miralles F et al.
Perception of Stigma in Patients with Neuromyelitis Optica Spectrum Disorder.
Patient Preference and Adherence, 2021, 15, 713-719, PMID: 33880015, FI: 2.314
Meca-Lallana V, Rodriguez-Antiguedad A, Llaneza MA, Meca-Lallana JE.
[Plasma determination of neurofilaments as biomarkers in multiple sclerosis: conclusions of the EMotion Forum].
Revista de Neurologia, 2021, 73, 101-110, PMID: 34291447, FI: 1.235
Fernandez O, Montalban X, Aladro Y, ..., Meca-Lallana J et al.
13th Post-ECTRIMS Meeting: review of the new developments presented at the 2020 ECTRIMS Congress (II).
Revista de Neurologia, 2021, 72, 433-442, PMID: 34109999, FI: 1.235
Fernandez O, Montalban X, Aladro Y, ..., Meca-Lallana J et al.
13th Post-ECTRIMS Meeting: review of the new developments presented at the 2020 ECTRIMS Congress (I).
Revista de Neurologia, 2021, 72, 397-406, PMID: 34042168, FI: 1.235
AYUDAS CONCEDIDAS EN 2021
TOTAL DE AYUDAS CONCEDIDAS
3
Nº Ayudas
0.44M €
Financiación
TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS
0
Nº Ayudas
0.0M €
Financiación
TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS
0
Nº Ayudas Europeas
0.0M €
Financiación Europea
2
Nº Ayudas Nacionales
0.3M €
Financiación Nacional
0
Nº Ayudas Regionales
0.0M €
Financiación Regional
TOTAL DE REDES CONCEDIDAS
1
Nº Ayudas
0.14M €
Financiación
OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)
0
Nº Ayudas
0.0K €
Financiación
PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2021
18
TOTAL AYUDAS
3
RECURSOS HUMANOS
0
REDES
1
PROYECTOS INTERNACIONALES
11
PROYECTOS NACIONALES
3
PROYECTOS REGIONALES
INICIADA EN 2021
6
Nº Estudios
4
Nº Ensayos Clínicos
1
Nº Producto Sanitario
0
Nº Estudios Post-Autorización
1
Nº Otros Estudios
ACTIVOS EN 2021
50
Nº Estudios
27
Nº Ensayos Clínicos
7
Nº Producto Sanitario
12
Nº Estudios Post-Autorización
4
Nº Otros Estudios
FACTURACIÓN EN 2021
0.21M €
Facturado
7
Nº Tesis (0 con mención internacional)
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